1,500 1,000 500 0 Number of beam breaks -4 10 24 38 52 66 80 94 108 122 136 150

Question

1,500 1,000 500 0 Number of beam breaks -4 10 24 38 52 66 80 94 108 122 136 150 Number of Infrared Beam Breaks by Mice Treated with CNO or Saline, by Sex Minutes from treatment females with saline males with saline males with CNO females with CNO All values are approximate. The following 4 lines are shown: females with CNO females with saline males with CNO males with saline The females with CNO line:� Begins at negative 4, 500 Rises sharply to 10, 735 Rises sharply to 24, 1,100 Rises sharply to 38, 1,400 Falls sharply to 52, 1,000 Rises gradually to 66, 1,050 Falls gradually to 80, 980 Falls sharply to 94, 735 Falls gradually to 108, 700 Falls sharply to 122, 500 Remains level to 136, 500 Falls sharply to 150, 350 The females with saline line:� Begins at negative 4, 500 Rises gradually to 10, 550 Falls gradually to 24, 505 Falls sharply to 38, 250 Falls sharply to 52, 75 Rises sharply to 66, 450 Falls gradually to 80, 350 Falls sharply to 94, 175 Remains level to 108, 175 Falls gradually to 122, 100 Rises gradually to 136, 175 Rises gradually to 150, 200 The males with CNO line:� Begins at negative 4, 450 Rises gradually to 10, 530 Rises gradually to 24, 600 Falls gradually to 38, 550 Falls gradually to 52, 530 Falls gradually to 66, 500 Falls gradually to 80, 450 Remains level to 94, 450 Rises gradually to 108, 475 Falls sharply to 122, 235 Falls gradually to 136, 210 Falls gradually to 150, 205 The males with saline line:� Begins at negative 4, 400 Rises sharply to 10, 505 Falls sharply to 24, 350 Falls gradually to 38, 275 Falls sharply to 52, 100 Rises sharply to 66, 225 Falls sharply to 80, 75 To investigate the influence of certain estrogen-responsive neurons on energy expenditure, biologist Stephanie Correa et al. treated female and male mice with either saline solution or clozapine-N4-oxide (CNO), which activates the neurons. Monitoring the activity levels of the mice by measuring how frequently the animals broke infrared beams crossing their enclosures, Correa et al. found that the mice in their study showed sex-specific differences in response to neuron activation: ______ blank Which choice most effectively uses data from the graph to complete the assertion?

Accepted Answer

Choice C is the best answer. The graph shows that the CNO-treated females were way more active than the CNO-treated males, while the saline-treated males and females (the control groups) had very similar activity levels. This supports the claim that there were sex-specific differences in the mice’s response to neuron activation.

Choice A is incorrect. This choice misreads the graph. All four groups of mice started at nearly the same activity level before treatment (see how all four points are very close together at -4 minutes, meaning four minutes before treatment). Choice B is incorrect. This choice doesn’t complete the assertion. The assertion is about the mice’s response to neuron activation, so we need to include the data about the CNO-treated females and males. Choice D is incorrect. This choice misreads the graph. The line for the CNO-treated males does not show a “substantial decline” until around 122 minutes, and there is no “steep increase” afterward.

Question 1500-1

1,500 1,000 500 0 Number of beam breaks -4 10 24 38 52 66 80 94

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